1. INTRODUCTION:

The major hindrance in the amalgamation of herbal medicines into modern clinical therapy is the lack of scientific and clinical data, and better understanding of the efficacy and safety of the herbal products. To ensure the quality, safety and standardization of such products is the challenging task for phytochemists and the medicinal chemists of the present and future era. The holistic approaches provided valuable clues for selection and preparation of such formulation, as efficacy has been established by the common use.^[1] In the last few decades there has been an exponential growth in the field of herbal medicine and the populariety of herbal drugs in the developed countries due to its natural origin with lesser side effects.^[2]

Majority of the traditional medicines used in healthcare are obtained from plants.^[3]In spite of several advancements in the field of clinical and pharmaceutical investigations have in fact elevated the status of medicinal plants by identifying the role of active principles present in them and elaborating on their mechanism of action in the human system.^[4] The WHO estimated that approximately 80% of world population trusts on traditional medicines in their health care but now a days Ayurveda coexists with modern system of medicine widely used in practice.^[5] In the traditional system of medicine lot of practitioners used their own formulation.^[6] Cressa cretica (Linn) is commonly known as Rudravanti and belonging to family Convolvulaceae.^[7] Cressa cretica (Linn) a halophytic plant which is referred to by the name that reflects the features of Sanjeevani so it is called Sanjeevani. It is mysterious and sought after herbs in India mythology. It’s existence and identity are steeped in deep controversy.^[8]

2. SYNONYMS:

Rudravanti, Uppugaddi, Dahna, Chaval, Uppusanaga, Mullumaddugida, Lona, Rudanti, Azhukanni, Uppu Marikkozhundu, Oan.

3. GEOGRAPHICAL DISTRIBUTION:

Cressa cretica (Linn) is a small, dwarf shrub upto 38 cm height. It is start to shoot in the beginning of June. The height of the plant was found to be 7 cm-29 cm but mostly are of 14 cm in hight. The time of fruits and flowers from June to August but during September the plant gradually withers. The plant is distributed throughout India, along sandy shores.^[9,10]

4. BOTANICAL DESCRIPTION:

Cressa cretica is a cushion chemaephyte excretive halophyte, an erect dwarf twining shrub up to 38 cm in height. Roots horizontal geminate, with lateral branches leading upward to produce above-ground parts. Perennial subshrub or herb, usually much-branched. Stems at first erect and then becoming decumbent, apparently short-lived, grey appressed pilose to sericeous.The flowers are actinomorphic, often showy, and nearly always bisexual.^[11] The perianth and androecial whorls are 5-merous. The sepals of the calyx are usually distinct but the corolla is strongly sympetalous, plaited, and often rotate or trumpet shaped with inconspicuous lobes. The stamens are often unequal, and are adnate to the base of the corolla tube and alternate with the lobes. The gynoecium consists of a single compound pistil of 2 or rarely up to 5 carpels, usually an unbranched or 2-cleft style, and a superior ovary of 2 or sometimes up to 5 locules, each with 1 or 2 axile ovules.^[12]

Young stems herbaceous, more or less cylindrical to oval in shape and slightly swollen at nodes. Stem at young tips more or less rectangular with deep green colour, odour remarkable, taste unpleasant and sour. Leaves on main branches are often larger than those on branchlets, the blade 1- 12mm long, lanceolate, ovate or elliptic to scale-like, sessile or shortly petiolate. Flowers solitary, axillary, 5- 8mm long, sessile or on short peduncles, bracteate, in spicate to head-like clusters at tips of branchlets, bracteoles unequal in length.^[13] Sepals ovate to obovate, imbricate. Corolla salver form, the limb 5-lobed, the lobes mostly ovate, imbricate, spreading to reflexed. Stamens exserted; filaments filiform; styles exserted. Ovary 2-locular, 4-ovulate; styles 2, distinct to the base; stigmas capitate. Fruit capsular, ovoid, unilocular, 2-4-valved, usually 1 seeded. Seeds 3- 4mm long, glabrous and smooth and shining to reticulate, dark brown.^[14]

5. CHEMICAL CONSTITUENTS

S.N.	Part of Plant	Extract/Tech.	Isolated Chemical Constituents	Ref. No.
1	Whole Plant	Atomic absorption and U.V. spectrophotometry	Cu, Al, Ca, Mn, P, S, Zn, Fe, Mg	[15]
2	Whole Plant	fixed oil extract	β- sitosterol, stigmasterol, avenasterol, β- tocopherol.	[16]
3	Seeds	Edible oil	Twelve unsaturated & four saturated fatty acids	[17]
4	Whole Plant	Atomic absorption spectroscopy	Four common heavy metals lead, zinc, copper and nickel	[18]
5	Whole Plant	EIMS, HREIMS, FAB, HRFABMS, NMR	Triacontanoic acid, 24-hydroxy-4 octacosanone, 24-nor-12-ursene, β-amyrin, stigmasterol, ursolic acid, and stigmasterol 3-O-β-D-glucoside,	[19]
6	Aerial parts	UV, FAB-MS, ₁H NMR and ¹³C NMR	quercetin, quercetin-3-O-glucoside, kampferol-3-O- glucoside, kampferol-3-O-rhamnoglucoside and rutin.	[20]
7	Aerial part	Column chromatography	Cressanyl ester A, B, C, D, E, F and G, and cressatriterpenic acid.	[21]
8	Aerial part	₁H NMR and ¹³C NMR	syringaresinol-β-d-glucoside	[22]
9	Shrub	Aqueous extract	Chemical analysis of minerals	[23]
10	Fruits	Alc. Extract	7,4'-dihydroxy-5 methoxy Coumaranochromone-7-O-β-D-glucoside	[24]
11	Aerial parts	Column chromatography	Quercetin glycoside	[25]
12	Aerial parts	₁H NMR and ¹³C NMR, MASS spectroscopy	Β-sitosterol, its glycoside, n-octacosanol, umbelliferone, scopoletin, isopimpinellin and quercetin	[26]
13	Whole Plant	Ehanolic extract	26-cyclopentyl hexacosane (creticane), 4?-methyl hexa-5¢-enoyl-n-tetracosa-17-ol-1-oate (cressatetracosanoate), n-nonacosa-6-one-1-oic (cressanonacontanoic acid), tetratriaconta-29-one-1-oic acid (cressatetratriacontanoic acid), 25-methyl-n-triacont-3-one-25-ol acid (cressatriacontanone) and a-26-octadeca-hydronaphthacenyl-n-pentacosa-3-one (cressanaphthacenone)	[27]
14	Aerial parts	Ehanolic extract	n-Octacosanol, β-sitosterol, umbelliferone, scopoletin, isopimpinellin, β-sitosterol D (+) glucoside and quercetin.	[28]

6. BIOLOGICAL ACTIVITIES

S.N.	Part of Plant	Extract Used	Biological activity	Ref. No.
1	Whole Plant	Methanolic extract	Antimicrobial activity	[29]
2	Whole Plant	water extract	Germination of pollen grains	[30]
3	Whole Plant	Ethylacetate and methanolic extract	Bronchodilatory activity and mast cell stabilising activity.	[31]
4	Aerial parts	Methanolic and ethyl acetate extract	Anti-inflammatory activity and Antioxidant activities	[32]
5	Whole Plant	Methanolic extract	Antitussive activity	[33]
6	Whole Plant	Crude solvent extract	Antifungal activity	[34]
7	Whole Plant	Aqueous and alcoholic extract	Antibacterial activity	[35]
8	Whole Plant	Aqueous and alcoholic extracts	Antibacterial activity	[36]
9	Whole Plant	n-butanol extracts	Antioxidant and radical scavenging activity	[37]
10	Whole Plant	n-butanol extract	Phosphomolybdenum complex assays and the radical scavenging activity	[38]
11	Whole Plant	Methanolic extract	Testicular function	[39]
12	Whole Plant	Ethanolic extract	antifungal activities	[40]
13	Whole Plant	Alcoholic extract	Contraceptive properties	[41]
14	Whole Plant	Ethanolic extract	Protective effective	[42]

7. USES:

The plant Cressa cretica used as tonic, stomachic, anthelmintic with aphrodisiac properties. It is useful for the treatment of asthma, constipation, leprosy and urinary discharges.^[43] Traditionally it is used as stomachic, anti bilious, expectorant, asthma, emetic and also used as alterative drug.^[44-46]

8. CONCLUSION:

Rudravanti (Cressa cretica) emerged as a good source of traditional medicine for the treatment of antimicrobial, bronchodilatory, anti-inflammatory, antioxidant, antitussive, antifungal, antibacterial activity. Although many of the experimental studies validated its traditional and medicinal uses. The study of herbal medicine spans the knowledge of biology, history, source, physical and chemical nature, mechanism of action, traditional, medicinal and therapeutic use of drug. This article also provide knowledge about macroscopical and microscopial characters of rudravanti with knowledge of its cultivation, collection and harvesting with its geographical sources. Efforts are therefore needed to establish and validate evidence regarding safety and practices of ayurvedic medicines. The outcome of these studies will further expand the existing therapeutic potential of Cressa cretica and provide a convincing support to its future clinical use in modern medicine.

9. REFERENCES:

1. Seth S.D, Sharma B. Medicinal plants of India. Indian J. Med. Res., 2004, Vol-120, 9-11.

2. Patel, B. V., A seminar report on herbal drugs, present status and future prospects, perd centre, Ahmedabad, 2001.

3. Kala, C. P., farooquee, N. A., Dhar, U., Prioritization of medicinal plants on the basis of available knowledge, existing practices and use value status in Uttaranchal, India, Biodiversity and conservation. 2004, Vol.-13, 453-469.

4. Dutta, S. C., Medicinal Plants, National council for education research and training, New Delhi, 1973.

5. Research guidelines for evaluating the safety and efficacy of herbal medicines, WHO, regional office for the Western pacific, Manila, 1993, 1-3.

6. Seth S.D, Sharma B. Medicinal plants of India. Indian J. Med. Res., 2004, Vol-120, 9-11.

7. Aggarwal, V. S., Drug plants of India, 1997, Vol.-I, 300.

8. Ganeshaiah, K. N., Vasudeva, R., Uma Shanker, R., In search of Sanjeevani. Curr Sci. 2009, Vol-97, 484-489.

9. Saxena, H. O., Brahmam, M., The Flora of Orissa, Bhubaneswar., Capital business services and consultancy; 1995, Vol-3, 1563.

10. Warrier, P. K., Nambier, V. P., Ramankutty, C., Indian medicinal plant a compendium of 500 species. CSIR, New Delhi India, 1990, Vol-1, 219.

11. Daniel, F., Austin, A., Botanical journal of the linnean society, 2000, Vol-133(1), 27-39.

12. Ganeshaiah, K. N., Vasudeva, R., Uma Shanker, R., In search of Sanjeevani. Curr Sci. 2009, Vol-97, 484-489.

13. Saxena, H. O., Brahmam, M., The Flora of Orissa, Bhubaneswar., Capital business services and consultancy; 1995, Vol-3, 1563.

14. Warrier, P. K., Nambier, V. P., Ramankutty, C., Indian medicinal plant a compendium of 500 species. CSIR, New Delhi India, 1990, Vol-1, 219.

15. Pirzada, A. J. Shaikh, W. Ghani, K. U. Laghari, K. A. Sindh University Research Journal (Science Series). 2009, Vol-41(2), 15-20.

16. Mohamed, I. I. Bulletin of Faculty of Agriculture, Cairo University. 2007, 58(4), 251-255.

17. Weber, D.J., Ansari, R., Gul, B., Ajmal Khan, M., “Potential of halophytes as source of edible oil.” Journal of Arid Environments., 2007, Vol- 68(2), 315-321.

18. S. Raje, R.T. Sane, K. Mangaonkar, S. Shailajan, G. Pathak, N. Jariwala, D. Kasar, Journal of the Indian Chemical Society. 2006 ,Vol.- 83(6), 611-612.

19. S. Hussain, E. Ahmed, A. Malik, A Jabbar, M. Arshad, Journal of the Chemical Society of Pakistan. 2005, Vol.- 27(3), 296-298.

20. A.A Shahat, N.S. Abdel-Azim, L. Pieters, A.J. Vlietinck. Pharmaceutical Biology.2004, Vol.- 42(4-5), 349-352.

21. Ramidi Ramachandran Mohd. Ali. Isolation and characterization of acyclic terpenic constituents from Cressa cretica aerial parts. Journal of Medicinal and Aromatic Plant Sciences. 2003, Vol.- 25(1), 81-90.

22. A.A. Shahat, N.S. Abdel-Azim, L. Pieters, A.J. Vlietinck. Fitoterapia. 2004, Vol.-75(7-8), 771-773.

23. R. P. Rastogi, B.N. Mehrotra. Compendium of Indian Medicinal plants. Central Drug Research Institute, Lucknow and National institute of science communication and information resources, New Delhi, Vol.-I, 2004, 126.

24. B. Ahmed. Cresoside: a new coumaranochromone glycoside from fruits of Cressa cretica Linn Indian Journal of Natural Products 1998, Vol.-14(2), 29-32.

25. R. P. Rastogi, B.N. Mehrotra. Compendium of Indian Medicinal plants. Central Drug Research Institute, Lucknow and National institute of science communication and information resources, New Delhi, Vol. II, 2006, 217.

26. R. P. Rastogi, B.N. Mehrotra. Compendium of Indian Medicinal plants. Central Drug Research Institute, Lucknow and National institute of science communication and information resources, New Delhi, Vol. III, 2005, 254.

27. Ramachandrun, R. Ali, M. Mir, R.S. “Isolation and charactrization of aliphatic constituents from Cressa cretica aerial parts.” J. Saudi Chem. Soc., 2004, Vol-8, 523-530.

28. Tiwari HP, Kakkar A., “Phytochemical examination of Cressa cretica Linn. (Rudanti).” Journal of the Indian Chemical Society, 1990, Vol.-67(9), 785.

29. Sunita, P., Jha, S., Pattanayak, S. P., Mishra, S. K., “Antimicrobial activity of a halophytic plant Cressa cretica L.” Journal of Scientific Research., 2012, Vol-4, 1, 203-212.

30. Kumbhar, B. A., Patel, G. R., “Effect of allelochemicals from Cressa cretica L. on in vitro pollen germination of Cajanus cajan (L.) mill sp.” Bioscience Discovery., 2012, Vol-3(2),169-171.

31. Priyashree, S., Jha, S., Pattanayak, S. P., “Bronchodilatory and mast cell stabilising activity of Cressa cretica L. Evaluation through in vivo and in vitro experimental models.” Asian Pacific Journal of Tropical Medicine., 2012, Vol-5(3), 180-186.

32. Sunita, P., Jha, S., Pattanayak, S. P., “Anti-inflammatory and in-vivo Antioxidant activities of Cressa cretica Linn., a halophytic plant.” Middle-East Journal of Scientific Research., 2011, Vol- 8(1), 129-140.

33. Sunita, P., Jha, S., Pattanayak, P. S., “In-vivo antitussive activity of Cressa cretica Linn. Using cough model in rodents.” Pharmacognosy Research., 2009, Vol-1(3), 157-161.

34. Pirzada, A. J., Shaikh, W., Ghani, K. U., Laghari, K. A., “Study of antifungal activity and some basic elements of medicinal plant Cressa cretica Linn against fungi causing skin diseases.” Sindh Univ. Res. Jour., 2009, Vol-41(2), 15-20.

35. Parekh, J., Chanda, S. V., “Antibacterial Activity of aqueous and alcoholic extracts of 34 Indian medicinal plant against some staphylococcus species.” Turk J Biol, 2008, Vol-32, 63-71.

36. Chanda S., Parekh, J., “In vitro screening of antibacterial activity of aqueous and alcoholic extracts of various Indian medicinal plant species against selected pathogens from Enterobacteriaceae.” African Journal of Microbiology Research, 2007, Vol.-1(6), 092-99.

37. Saleh, A. B., Mubarak, A. R., Khadija, A. O., Abdulkhader, H., “Screening of antioxidant and radical scavenging activities os some omani medicinal plants.” SQU Journal for Science. 2007, Vol-12(1), 1-6.

38. Busafi SA, Riyami AM, Khadija AO, Hisham A, “Screening of Antioxidant and Radical Scavenging Activities of Some Omani Medicinal Plants.” SQU Journal For Science, 2007 Vol.- 12(1), 1-6.

39. Gupta, R. S. Kachhawa JBS Khushalani, V. Tanwar, K. Joshi, Y. C., “Effect of Cressa cretica methanol extract on testicular function of albino rats.” Pharmaceutical Biology, 2006. Vol- 44(5), 382-388.

40. Mandeel Q, Ahmed T., “Assessment of in vitro antifungal activities of various extracts of indigenous Bahraini medicinal plants.” Pharmaceutical Biology., 2005, Vol-43 (4), 340-348.

41. M. J Shah, S. Fazil, T. Faheem, A. Waheed. Hamdard Medicus. 1997. Vol.-40(2), 34-36.

42. S Satakopan , GK Karandikar. J Sci Ind Res, C Biol Sci. 1961, Vol.- 20,156.

43. Pragati, K., Ghanshyam, Y., Sudhir, C., Lubhan, S., Investigation on protective effective of Cressa cretica extract in scopolamine induced memory impairment. International Journal of Pharmacology & Toxicology., 2014, Vol.- 2(1),13-16.

44. AM Rizk, GA El-Ghazaly. Medicinal and Poisonous Plants of Qatar. University of Qatar. Scientific and Applied Research Centre. 1995,101.

45. C.P. Khare, Indian medicinal plants, Springer (India) Private Limited, 2007, 177-178.

46. Hocking Macdonald G. A Dictionary of Natural Products. Medford, N.J.7 Plexus Publishing, 1997.

Received on 28.05.2015 Modified on 12.06.2015

Res. J. Pharmacology & P’dynamics. 7(3): July-Sept., 2015; Page 119-123

DOI: 10.5958/2321-5836.2015.00022.1